The role of melatonin in pathogenesis of aspirin-sensitive asthma.


BACKGROUND Platelets are involved in the pathogenesis of bronchial asthma, including aspirin-sensitive asthma (ASA). The pineal hormone melatonin (MT) has been described as inhibiting several physiological processes in platelets. The MT metabolite - N-acetyl-5-methoxy-kynurenamine - has a chemical structure similar to that of acetylsalicylic acid. Because… (More)