The role of melanogenesis in regulation of melanoma behavior: melanogenesis leads to stimulation of HIF-1α expression and HIF-dependent attendant pathways.

@article{Slominski2014TheRO,
  title={The role of melanogenesis in regulation of melanoma behavior: melanogenesis leads to stimulation of HIF-1α expression and HIF-dependent attendant pathways.},
  author={Andrzej T Slominski and T-K Kim and Anna Aneta Brożyna and Zorica Janjetovic and Danielle L. Peacock Brooks and Luciana P. Schwab and Cezary Skobowiat and Wojciech J{\'o}źwicki and Tiffany N Seagroves},
  journal={Archives of biochemistry and biophysics},
  year={2014},
  volume={563},
  pages={79-93}
}
To study the effect of melanogenesis on HIF-1α expression and attendant pathways, we used stable human and hamster melanoma cell lines in which the amelanotic vs. melanotic phenotypes are dependent upon the concentration of melanogenesis precursors in the culture media. The induction of melanin pigmentation led to significant up-regulation of HIF-1α, but not HIF-2α, protein in melanized cells for both lines. Similar upregulation of nuclear HIF-1α was observed in excisions of advanced melanotic… CONTINUE READING

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