The role of mechanistic toxicology in test method validation.

  title={The role of mechanistic toxicology in test method validation.},
  author={John M. Frazier},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  volume={8 4},
  • John M. Frazier
  • Published 1994 in
    Toxicology in vitro : an international journal…
There are two approaches to in vitro toxicity test validation, phenomenological and mechanistic. The phenomenological approach uses correlative mathematical techniques, with no regard to the identification of mechanistic relationships, to relate in vitro measurements of toxicity to in vivo toxicological responses in order to establish the validity of the methods under consideration. This approach has three major limitations: (1) success or failure of a particular test will depend critically on… CONTINUE READING

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