The role of mechanics in the growth and homeostasis of the intestinal crypt

  title={The role of mechanics in the growth and homeostasis of the intestinal crypt},
  author={A A Almet and Helen M. Byrne and P. K. Maini and Derek E. Moulton},
  journal={Biomechanics and Modeling in Mechanobiology},
  pages={585 - 608}
  • A. Almet, H. Byrne, +1 author D. Moulton
  • Published 30 May 2020
  • Medicine, Physics, Chemistry
  • Biomechanics and Modeling in Mechanobiology
We present a mechanical model of tissue homeostasis that is specialised to the intestinal crypt. Growth and deformation of the crypt, idealised as a line of cells on a substrate, are modelled using morphoelastic rod theory. Alternating between Lagrangian and Eulerian mechanical descriptions enables us to precisely characterise the dynamic nature of tissue homeostasis, whereby the proliferative structure and morphology are static in the Eulerian frame, but there is active migration of Lagrangian… 

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