The role of matrix metalloproteinase-2 and matrix metalloproteinase-9 in antibody-induced arthritis.

  title={The role of matrix metalloproteinase-2 and matrix metalloproteinase-9 in antibody-induced arthritis.},
  author={Takeshi Itoh and Hidetoshi Matsuda and Masatoshi Tanioka and Kenji Kuwabara and Shigeyoshi Itohara and Ryuji Suzuki},
  journal={Journal of immunology},
  volume={169 5},
Matrix metalloproteinases (MMPs) are a large group of enzymes responsible for matrix degradation. Among them, the family of gelatinases (MMP-2/gelatinase A and MMP-9/gelatinase B) is overproduced in the joints of patients with rheumatoid arthritis. Because of their degradative effects on the extracellular matrix, gelatinases have been believed to play an important role in progression and cartilage degradation in this disease, although their precise roles are yet to be defined. To clarify these… CONTINUE READING


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