The role of mast cells in functional GI disorders

@article{Wouters2015TheRO,
  title={The role of mast cells in functional GI disorders},
  author={Mira M Wouters and Mar{\'i}a Vicario and Javier Santos},
  journal={Gut},
  year={2015},
  volume={65},
  pages={155 - 168}
}
Functional gastrointestinal disorders (FGIDs) are characterized by chronic complaints arising from disorganized brain-gut interactions leading to dysmotility and hypersensitivity. The two most prevalent FGIDs, affecting up to 16–26% of worldwide population, are functional dyspepsia and irritable bowel syndrome. Their etiopathogenic mechanisms remain unclear, however, recent observations reveal low-grade mucosal inflammation and immune activation, in association with impaired epithelial barrier… 

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