• Corpus ID: 33716552

The role of magnesium binders in chronic kidney disease.

@article{Spiegel2007TheRO,
  title={The role of magnesium binders in chronic kidney disease.},
  author={David M. Spiegel},
  journal={Seminars in dialysis},
  year={2007},
  volume={20 4},
  pages={
          333-6
        }
}
  • D. Spiegel
  • Published 2007
  • Medicine
  • Seminars in dialysis
Magnesium is predominantly an intracellular cation that plays a critical role in cellular physiology. Serum levels are often slightly elevated in patients on chronic hemodialysis and older reports suggests that total body stores may also be increased, based on bone biopsies in patients treated with higher dialysate magnesium levels than are currently in use today. Several studies have shown that magnesium, particularly in the form of magnesium carbonate, is an effective phosphate binder and can… 
Magnesium-based interventions for normal kidney function and chronic kidney disease.
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Although longitudinal data describe an association between low serum Mg levels and increased total and cardiovascular mortality, in patients with CKD, the existing RCTs reporting the effect of Mg supplementation on mortality failed to demonstrate any favorable effect, and the role of MG in CKD patients needs to be investigated in more depth.
Reviews: Clinical Implications of Disordered Magnesium Homeostasis in Chronic Renal Failure and Dialysis
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High Mg levels have been associated with impairment of myocardial contractility, intradialytic hemodynamic instability, and hypotension, and low Mg has been also linked to carotid intima‐media thickness, a marker of atherosclerotic vascular disease and a predictor of vascular events.
Magnesium metabolism in health and disease
  • C. Musso
  • Medicine
    International Urology and Nephrology
  • 2009
TLDR
Hypermagnesemia usually occurs in the setting of renal insufficiency and excessive Mg intake, and body excretion of Mg can be enhanced by use of saline diuresis, furosemide, or dialysis depending on the clinical situation.
Effect of calcium acetate/magnesium carbonate in the treatment of hyperphosphataemia in dialysis patients in real clinical practice. One year follow up.
TLDR
Analysis of current clinical practice shows that CaMg treatment leads to marked improvement in serum phosphorus levels, helping patients in trying to achieve K/DOQI and KDIGO (Kidney Disease Improving Global Outcome) targets.
Cardiovascular disease, mortality, and magnesium in chronic kidney disease: growing interest in magnesium-related interventions
  • R. Ikee
  • Medicine
    Renal Replacement Therapy
  • 2018
Magnesium (Mg) is an essential element that plays pivotal roles in a number of biological processes in the human body. Hypomagnesemia is involved in the pathophysiology of hypertension, vascular
Effects of the Use of Non-Calcium Phosphate Binders in the Control and Outcome of Vascular Calcifications: A Review of Clinical Trials on CKD Patients
  • P. Bolasco
  • Medicine
    International journal of nephrology
  • 2011
TLDR
Comparison and efficacy studies undertaken to assess the impact on morbidity and mortality rates of non-calcium phosphate binders are analyzed and the mechanism of action underlying the depositing of calcium and phosphate along blood vessel walls is investigated.
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TLDR
The role of phosphate control in determining patient outcomes must be quantified, which is likely to require a large randomized, controlled study of two levels of phosphate controlled by Oral phosphate binders.
Relationship Between Serum Parathyroid Hormone and Trace Elements (Serum Zinc and Magnesium) in Hemodialyzed Chronic Renal Failure Children
TLDR
There was a significant negative correlation between serum levels of PTH and zinc as well as an insignificantnegative correlation between P TH and serum magnesium in CRF patients, indicating that Elevated PTH may play a role in the pathogenesis of hypozincemia.
Evaluation of calcium acetate/magnesium carbonate as a phosphate binder compared with sevelamer hydrochloride in haemodialysis patients: a controlled randomized study (CALMAG study) assessing efficacy and tolerability
TLDR
CaMg was non-inferior to the comparator at controlling serum phosphorus levels at Week 25, and had a good tolerability profile and thus may represent an effective treatment of hyperphosphataemia.
Hypomagnesemia in Hemodialysis Patients: Role of Proton Pump Inhibitors
TLDR
Monitoring plasma [Mg] in patients taking PPIs, with discontinuation of the medication if possible and/or adjustment of dialysate [MG] to normalize plasma [ Mg] is suggested.
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