The role of mTOR in depression and antidepressant responses.

  title={The role of mTOR in depression and antidepressant responses.},
  author={Helena Mendes Abelaira and Gislaine Zilli R{\'e}us and Morgana V Neotti and Jo{\~a}o Quevedo},
  journal={Life sciences},
  volume={101 1-2},
The aim of this study was to characterize the mTOR signaling cascade in depression and the actions that antidepressant drugs have on this pathway. Herein, a literature review was performed by verification and comparison of textbooks and journal articles that describe the characterization of the mTOR signaling cascade and its relationship to depression and antidepressant drugs, especially ketamine. Postmortem studies have shown robust deficits in the mammalian target of rapamycin (mTOR… CONTINUE READING
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