The role of mRNA decay in p53-induced gene expression.

@article{Melanson2011TheRO,
  title={The role of mRNA decay in p53-induced gene expression.},
  author={Brian D. Melanson and Reetesh Bose and Jeff D. Hamill and Kristen A. Marcellus and Elysia F Pan and Bruce C McKay},
  journal={RNA},
  year={2011},
  volume={17 12},
  pages={2222-34}
}
The p53 tumor suppressor is a DNA-damage-responsive sequence-specific transcriptional activator. The sustained activation of the p53 response is incompatible with cell growth and viability. To circumvent this issue, a variety of negative feedback loops exist to limit the duration of p53 activation. Despite our understanding of p53 regulation, very little is… CONTINUE READING