The role of lymphatic obstruction in the formation of ascites in a murine ovarian carcinoma.

Abstract

obstruction of lymphatics draining the peritoneal cavity by tumor cells. In normal mice, the rapid egress of i.p.-injected India ink from the abdominal cavity through lymphatics is well documented (9, 13). Holm-Nielsen found that in mice rendered ascitic by tumor virtually no ink was transported through the lymphatics draining the abdominal cavity. Moreover, he presented micrographs from these ascitic animals which appeared to demonstrate occlusion of lymphatic channels by tumor cells. These studies did not determine whether the lymphatic obstruction precedes the formation of ascites and therefore is of pathogenetic significance in the formation, or whether the obstruction was merely an accompaniment of the ascites. Red blood cells that are free in the abdominal cavity enter the peripheral circulation only via the lymphatics (2, 13). Therefore, measurement of the appearance in the peripheral blood of @ â€C̃r-labeled erythrocytes injected i.p. allows a quantitative determination of the egress of erythrocytes through the lymphatics draining the abdominal cavity. Courtice et al. (1) found that 70% of labeled erythrocytes left the abdominal cavity of normal rats within 5 hr after they were given the injection. In our laboratory, a transplantable ovarian embryonal cell carcinoma is maintained by serial i.p. transfer in C3HeB/FeJ

2 Figures and Tables

050100'75'79'84'89'94'99'04'09'14
Citations per Year

748 Citations

Semantic Scholar estimates that this publication has 748 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Feldman1972TheRO, title={The role of lymphatic obstruction in the formation of ascites in a murine ovarian carcinoma.}, author={Geoffrey B. Feldman and Robert C. Knapp and Stanley E. Order and Samuel Hellman}, journal={Cancer research}, year={1972}, volume={32 8}, pages={1663-6} }