The role of luminal nutrients in intestinal injury from mesenteric reperfusion and platelet-activating factor in the developing rat.

@article{Bhatia1996TheRO,
  title={The role of luminal nutrients in intestinal injury from mesenteric reperfusion and platelet-activating factor in the developing rat.},
  author={Amina Mira Bhatia and Richard M. Feddersen and C. A. Musemeche},
  journal={The Journal of surgical research},
  year={1996},
  volume={63 1},
  pages={152-6}
}
Necrotizing enterocolitis (NEC) develops primarily after the onset of enteral feeds in the premature infant. The purpose of this study was to evaluate the influence of intestinal luminal nutrients on histologic injury and the oxidant response in a rat model of NEC. On postnatal Days 10 and 35, Sprague-Dawley rats (total n = 81) underwent abdominal laparotomy. A control group received sham-injury only. The ischemia groups received a single intraluminal injection of 0.25 ml (Day 10) or 1.0 ml… CONTINUE READING