The role of lubricin in the mechanical behavior of synovial fluid.

@article{Jay2007TheRO,
  title={The role of lubricin in the mechanical behavior of synovial fluid.},
  author={Gregory D. Jay and J R Torres and Matthew L Warman and Matthew C. Laderer and Kenneth S. Breuer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 15},
  pages={6194-9}
}
Synovial fluid is a semidilute hyaluronate (HA) polymer solution, the rheology of which depends on HA-protein interactions, and lubricin is a HA-binding protein found in synovial fluid and at cartilage surfaces, where it contributes to boundary lubrication under load. Individuals with genetic deficiency of lubricin develop precocious joint failure. The role of lubricin in synovial fluid rheology is not known. We used a multiple-particle-tracking microrheology technique to study the molecular… CONTINUE READING