The role of lipin 1 in adipogenesis and lipid metabolism.

@article{Reue2007TheRO,
  title={The role of lipin 1 in adipogenesis and lipid metabolism.},
  author={Karen Reue},
  journal={Novartis Foundation symposium},
  year={2007},
  volume={286},
  pages={58-68; discussion 68-71, 162-3, 196-203}
}
  • Karen Reue
  • Published 2007 in Novartis Foundation symposium
In conditions such as obesity and lipodystrophy, insulin resistance and diabetes are associated with the dysregulation of lipid metabolism in adipose tissue, skeletal muscle and liver. One factor that influences lipid homeostasis in all three of these tissues is lipin 1. Studies in mouse models and humans have established a relationship between lipin 1 levels and both triglyceride storage in adipose tissue and insulin sensitivity. Thus, lipin 1 deficiency in the mouse results in lipodystrophy… CONTINUE READING

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