The role of lipids and lipoproteins in atherosclerosis.

@article{Gofman1950TheRO,
  title={The role of lipids and lipoproteins in atherosclerosis.},
  author={John W. Gofman and Frank T. Lindgren},
  journal={Science},
  year={1950},
  volume={111 2877},
  pages={
          166-71
        }
}
A THEROSCLEROSIS is generally considered to be the major disease of this era. Its consequences in the coronary, cerebral, and peripheral arteries, in the form o£ ocelu- sive phenomena, are responsible for more death and disability than any other disease. In spite of much study and research there is still no agreement con- cerning the sequence of pathogenetic events, etiol- ogy, or treatment of atheroselerosis. The not-too- rare oceurrence of coronary artery ocelusions (almost always a… 
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For many years atherosclerosis was almost exclusively a province of the pathologists, but the discovery by Anitschkow and others in 1910-1912 that very similar lesions can be produced in rabbits by feeding cholesterol changed the picture drastically.
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Alterations in the metabolism of cholesterol with an abnormal accumulation of various components of lipids and lipoproteins appear to play an important part in the development of this disease.
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  • Medicine
    Annals of the New York Academy of Sciences
  • 1956
This section of this publication is concerned with methodology for the evaluation of atherosclerosis and its progression in order that the effect of potential prophylactic and therapeutic agents for
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    Annals of the New York Academy of Sciences
  • 1990
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It is shown that free cholesterol or its derivatives is probably more important as a hazard to the cells, since it is more likely to be incorporated into membranes where it may cause deviations in membrane fluidity and function.
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The present state of knowledge of lipid metabolism and vascular disease has been achieved by advances in many disciplines. The contributions of the basic sciences cannot be clearly separated from
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It is pointed out that substantial evidence for a causal relationship between hypercholesterolemia and atherosclerosis began to appear over 100 years ago and was already strong enough 40 years ago that it should have been persuasive.
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CORONARY ATHEROSCLEROSIS IN DIABETES MELLITUS: A POSTMORTEM STUDY
TLDR
Among nondiabetic patients, coronary artery disease is apparently largely responsible for the relatively recent and striking increase in deaths from heart disease in middle and late life.