The role of lipids and lipoproteins in atherosclerosis.
@article{Gofman1950TheRO,
title={The role of lipids and lipoproteins in atherosclerosis.},
author={John W. Gofman and Frank T. Lindgren},
journal={Science},
year={1950},
volume={111 2877},
pages={
166-71
}
}A THEROSCLEROSIS is generally considered to be the major disease of this era. Its consequences in the coronary, cerebral, and peripheral arteries, in the form o£ ocelu- sive phenomena, are responsible for more death and disability than any other disease. In spite of much study and research there is still no agreement con- cerning the sequence of pathogenetic events, etiol- ogy, or treatment of atheroselerosis. The not-too- rare oceurrence of coronary artery ocelusions (almost always a…
800 Citations
BIOCHEMICAL ASPECTS OF ATHEROSCLEROSIS
- MedicineJournal of the American Geriatrics Society
- 1954
For many years atherosclerosis was almost exclusively a province of the pathologists, but the discovery by Anitschkow and others in 1910-1912 that very similar lesions can be produced in rabbits by feeding cholesterol changed the picture drastically.
Lipid metabolism and atherosclerosis.
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- 1965
This change in concept came at a time when the infectious diseases had in large part been mastered and when diseases of the heart and blood vessels were becoming foremost among the afflictions of mankind; and it was soon to have a stimulating influence on thought and experiment in the field of vascular disease.
A Study of Serum Lipoprotein and Cholesterol Determinations in 901 Diabetics
- Medicine, BiologyDiabetes
- 1957
For over ioo years pathologists have recognized that the lipid laden intimal plaque impinging upon the lumen of the arteries is the characteristic feature of atherosclerosis. The dogma that it was an…
The George E. Brown Memorial Lecture: Some Chemical Factors in the Pathogenesis of Atherosclerosis
- MedicineCirculation
- 1953
It has been demonstrated that the administration of estrogen can convert the highly pathologic patterns of survivors of myocardial infarction to normal adult human values, and that the use of methyl testosterone exaggerates the chemical pathology of the disease and may even produce deviant patterns in those who have been previously normal.
Lipoprotein studies in diabetics with arteriosclerotic disease.
- MedicineJournal of the American Medical Association
- 1954
Alterations in the metabolism of cholesterol with an abnormal accumulation of various components of lipids and lipoproteins appear to play an important part in the development of this disease.
SERUM LIPOPROTEINS AND THE EVALUATION OF ATHEROSCLEROSIS
- MedicineAnnals of the New York Academy of Sciences
- 1956
This section of this publication is concerned with methodology for the evaluation of atherosclerosis and its progression in order that the effect of potential prophylactic and therapeutic agents for…
The Involvement of Lipoproteins in Atherogenesis Evolving Concepts a
- BiologyAnnals of the New York Academy of Sciences
- 1990
It is shown that free cholesterol or its derivatives is probably more important as a hazard to the cells, since it is more likely to be incorporated into membranes where it may cause deviations in membrane fluidity and function.
Triglycerides, lipoproteins, and coronary artery disease.
- MedicineArchives of internal medicine
- 1962
The present state of knowledge of lipid metabolism and vascular disease has been achieved by advances in many disciplines. The contributions of the basic sciences cannot be clearly separated from…
THE PHOSPHOLIPID‐CHOLESTEROL RELATIONSHIP IN HUMAN PLASMA: ITS IMPLICATIONS IN THE ATHEROSCLEROSIS PROBLEM
- BiologyJournal of the American Geriatrics Society
- 1953
Growing interest in the problem of atherosclerosis, and a change in attitude toward this disease, have combined to produce the remarkable amount of work in this field which has characterized the last twenty years.
The Pathogenesis of Atherosclerosis An interpretive history of the cholesterol controversy , part III : mechanistically defining the role of hyperlipidemia 1
- Medicine
- 2005
It is pointed out that substantial evidence for a causal relationship between hypercholesterolemia and atherosclerosis began to appear over 100 years ago and was already strong enough 40 years ago that it should have been persuasive.
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