The role of lifetime stressors in adult fibromyalgia: systematic review and meta-analysis of case-control studies

@article{Kaleycheva2021TheRO,
  title={The role of lifetime stressors in adult fibromyalgia: systematic review and meta-analysis of case-control studies},
  author={Nia Kaleycheva and Alexis E. Cullen and Robyn Evans and Tirril Harris and Timothy R Nicholson and Trudie Chalder},
  journal={Psychological Medicine},
  year={2021},
  volume={51},
  pages={177 - 193}
}
Abstract Background Fibromyalgia is a chronic condition characterised by widespread musculoskeletal pain. Although accumulating evidence suggests that exposure to stressful events increases the risk for this complex disorder, this is the first meta-analysis to compare the impact of a full range of lifetime stressors (e.g. physical trauma through to emotional neglect) on adult fibromyalgia. Methods This review was performed in accordance with PRISMA guidelines. Random-effects models examined… 
Role of stressors in adult fibromyalgia - a response to Kaleycheva et al.
TLDR
Patients with fibromyalgia will have more availability of access to previously distressing events in their memory, and no convincing evidence is presented in this meta-analysis that the relationships discovered are no more than a response to simply being in pain.
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Findings demonstrated that in chronic pain, ACEs are associated with increased pain complications, pain catastrophizing and depression and the combination of these factors further heightens the risk of early treatment attrition.

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