The role of lic2B in lipopolysaccharide biosynthesis in Haemophilus influenzae strain Eagan.

@article{Twelkmeyer2011TheRO,
  title={The role of lic2B in lipopolysaccharide biosynthesis in Haemophilus influenzae strain Eagan.},
  author={Brigitte Twelkmeyer and Mary E. Deadman and Ehsanul Haque and Jianjun Li and Derek W Hood and Elke K.H. Schweda},
  journal={Carbohydrate research},
  year={2011},
  volume={346 10},
  pages={1262-6}
}
Lipopolysaccharide (LPS) biosynthesis in Haemophilus influenzae involves genes from the lic2 locus that are required for chain extension from the middle heptose (HepII) of the conserved triheptosyl inner-core moiety. Lic2C initiates the process by attaching the first glucose to HepII, but the gene encoding for the enzyme adding the next β-D-Glcp- is uncharacterized. Lic2B is the candidate glucosyltransferase; however, in previous investigations, mutation of lic2B resulted in no hexose extension… CONTINUE READING