The role of leukotrienes in the pathophysiology of inflammatory disorders: Is there a case for revisiting leukotrienes as therapeutic targets?

@article{Sharma2006TheRO,
  title={The role of leukotrienes in the pathophysiology of inflammatory disorders: Is there a case for revisiting leukotrienes as therapeutic targets?},
  author={Jagdish Narain Sharma and Leena Mohammed},
  journal={InflammoPharmacology},
  year={2006},
  volume={14},
  pages={10-16}
}
Leukotrienes (LTs), a family of lipid mediators, play a key role in the pathogenesis of inflammation. They are synthesized in the leucocytes from arachidonic acid (AA) via the actions of 5-lipoxygenase (5-LO). LTs are classified into two classes: LTB4 and cysteinyl LTs (CysLTs). LTB4 is one of the most potent chemoattractant mediators of inflammation. It exerts its actions through a seven transmembrane-spaning G protein receptors, LTB4 R-1 and LTB4 R-2. CysLTs (LTC4, LTD4, and LTE4) are potent… CONTINUE READING
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