The role of leukotrienes in airway inflammation.

@article{Ogawa2006TheRO,
  title={The role of leukotrienes in airway inflammation.},
  author={Yoshiko Ogawa and William J. Calhoun},
  journal={The Journal of allergy and clinical immunology},
  year={2006},
  volume={118 4},
  pages={
          789-98; quiz 799-800
        }
}
Cysteinyl leukotrienes (cysLTs) are a class of closely structurally related lipid molecules, originally described as slow-reacting substance of anaphylaxis, with a myriad of biologic functions. These activities include producing smooth muscle contraction and mucus secretion, recruiting allergic inflammatory cells, modulating cytokine production, influencing neural transmission, and altering structural changes in the airway. Administration of cysLTs to animals and human subjects reproduces many… CONTINUE READING
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