The role of leptin in the regulation of TSH secretion in the fed state: in vivo and in vitro studies.

@article{OrtigaCarvalho2002TheRO,
  title={The role of leptin in the regulation of TSH secretion in the fed state: in vivo and in vitro studies.},
  author={T M Ortiga-Carvalho and Karen de Jesus Oliveira and Breno A. Soares and Carmen Cabanelas Pazos-Moura},
  journal={The Journal of endocrinology},
  year={2002},
  volume={174 1},
  pages={121-5}
}
Leptin has been shown to stimulate the hypothalamus-pituitary-thyroid axis in fasting rodents; however, its role in thyroid axis regulation under physiological conditions is still under investigation. Here it was investigated in freely fed rats whether leptin modulates thyrotroph function in vivo and whether leptin has direct pituitary effects on TSH release. Since leptin is produced in the pituitary, the possibility was also investigated that leptin may be a local regulator of TSH release. TSH… CONTINUE READING

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