The role of leptin and ghrelin in the regulation of food intake and body weight in humans: a review

  title={The role of leptin and ghrelin in the regulation of food intake and body weight in humans: a review},
  author={Melanie D. Klok and Sigridur Jakobsd{\'o}ttir and Madeleine L. Drent},
  journal={Obesity Reviews},
Leptin and ghrelin are two hormones that have been recognized to have a major influence on energy balance. Leptin is a mediator of long‐term regulation of energy balance, suppressing food intake and thereby inducing weight loss. Ghrelin on the other hand is a fast‐acting hormone, seemingly playing a role in meal initiation. As a growing number of people suffer from obesity, understanding the mechanisms by which various hormones and neurotransmitters have influence on energy balance has been a… 

The Role of Ghrelin and Leptin in Obesity: Is Exogenous Administration of These Hormones a Possible Drug Therapy?

Ghrelin and leptin are two hormones that have been recognized to have a major influence on energy balance. Leptin is a mediator of long term regulation of energy balance, suppressing food intake and

The role of ghrelin in the regulation of food intake in patients with obesity and anorexia nervosa.

The aim of this review is to summarize the current knowledge about the physiology and pathophysiology of ghrelin and to discuss its potential in the prevention and/or treatment of obesity and anorexia nervosa.

Ghrelin: are its levels related to obesity?

Ghrelin is an anabolic hor­mone and its levels change profoundly in obesity, suggesting that this is an important hormone in body weight regulation.


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The effects of water aerobic exercises on the levels of p lasma β-estradiol , Ghrelin and body composition in obese non-athlete women

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Current knowledge of the regulatory hormones in food intake in swine.

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Ghrelin-mediated appetite regulation in the central nervous system

Capromorelin: a ghrelin receptor agonist and novel therapy for stimulation of appetite in dogs

The data available on the safety and effectiveness of capromorelin is reviewed, along with a discussion of the potential clinical applications for ghrelin receptor agonists in both human and veterinary medicine.

Effects of second generation antipsychotics on leptin and ghrelin




Ghrelin levels are not regulated by recombinant leptin administration and/or three days of fasting in healthy subjects.

Cross-sectional and interventional studies do not support a role for regulation of circulating ghrelin by leptin levels independently of changes in adiposity and suggest that the leptin and Ghrelin systems for energy homeostasis function independently of each other in healthy humans.

Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, and resistin.

This review summarizes recent knowledge on leptin and its receptor and on ghrelin, adiponectin, and resistin and emphasizes their roles in pathobiochemistry and clinical chemistry.

Leptin signaling in the hypothalamus: emphasis on energy homeostasis and leptin resistance

  • A. Sahu
  • Biology
    Frontiers in Neuroendocrinology
  • 2003

Ghrelin induces adiposity in rodents

It is proposed that ghrelin, in addition to its role in regulating GH secretion, signals the hypothalamus when an increase in metabolic efficiency is necessary, suggesting an involvement in regulation of energy balance.

Leptin, gut, and food intake.

Neuroendocrine and metabolic effects of acute ghrelin administration in human obesity.

Obesity shows remarkable reduction of the somatotroph responsiveness to ghrelin, suggesting that gh Relin hyposecretion unlikely explains the impairment of somatOTroph function in obesity.

A role for ghrelin in the central regulation of feeding

It is shown that ghrelin is involved in the hypothalamic regulation of energy homeostasis and probably has a function in growth regulation by stimulating feeding and release of growth hormone.

Ghrelin enhances appetite and increases food intake in humans.

  • A. WrenL. Seal S. Bloom
  • Medicine, Biology
    The Journal of clinical endocrinology and metabolism
  • 2001
Ghrelin is the first circulating hormone demonstrated to stimulate food intake in man and is a potentially important new regulator of the complex systems controlling food intake and body weight.

Roles of leptin and ghrelin in the loss of body weight caused by a low fat, high carbohydrate diet.

It is concluded that weight loss early in the course of dietary fat restriction occurs independently of increased plasma leptin levels, but that a later increase in amplitude of the 24-h leptin signal may contribute to ongoing weight loss.

Weight gain decreases elevated plasma ghrelin concentrations of patients with anorexia nervosa.

Fasting plasma levels of the novel appetite-modulating hormone ghrelin are elevated in anorexia nervosa and return to normal levels after partial weight recovery, suggesting the possible existence of ghrel in resistance in cachectic states such as caused by eating disorders.