The role of leptin and ghrelin in the regulation of food intake and body weight in humans: a review

@article{Klok2007TheRO,
  title={The role of leptin and ghrelin in the regulation of food intake and body weight in humans: a review},
  author={Melanie D. Klok and Sigridur Jakobsd{\'o}ttir and Madeleine L. Drent},
  journal={Obesity Reviews},
  year={2007},
  volume={8}
}
Leptin and ghrelin are two hormones that have been recognized to have a major influence on energy balance. Leptin is a mediator of long‐term regulation of energy balance, suppressing food intake and thereby inducing weight loss. Ghrelin on the other hand is a fast‐acting hormone, seemingly playing a role in meal initiation. As a growing number of people suffer from obesity, understanding the mechanisms by which various hormones and neurotransmitters have influence on energy balance has been a… 

The Role of Ghrelin and Leptin in Obesity: Is Exogenous Administration of These Hormones a Possible Drug Therapy?

Ghrelin and leptin are two hormones that have been recognized to have a major influence on energy balance. Leptin is a mediator of long term regulation of energy balance, suppressing food intake and

The role of ghrelin in the regulation of food intake in patients with obesity and anorexia nervosa.

The aim of this review is to summarize the current knowledge about the physiology and pathophysiology of ghrelin and to discuss its potential in the prevention and/or treatment of obesity and anorexia nervosa.

Ghrelin: are its levels related to obesity?

Ghrelin is an anabolic hor­mone and its levels change profoundly in obesity, suggesting that this is an important hormone in body weight regulation.

EFFECT OF EXERCISE ON APPETITE-REGULATING HORMONES IN OVERWEIGHT WOMEN

The data indicated that although acute treadmill exercise resulted in a significant change in acyl ghrelin and leptin levels, it had no effect on plasma obestatin and des-acyl gh Relin levels.

DIABETES OR OBESITY; MAJOR EFFECTOR OF ALTERED LEVELS OF GHRELIN AND LEPTIN

It is evident from the study that low levels of ghrelin are predominantly associated with diabetes parameters when compared to parameters of obesity and on the contrary increased leptin levels have much stronger association with measures of obesity than diabetes.

The effects of water aerobic exercises on the levels of p lasma β-estradiol , Ghrelin and body composition in obese non-athlete women

Ghrelin is a peptide secreted in the stomach. Ghrelin plays an important role in the secretion of growth hormone, energy balance, obesity, food intake behavior and some cardiovascular functions

Current knowledge of the regulatory hormones in food intake in swine.

This paper is a review about research of insulin, leptin and ghrelin in pigs and their implications in regulation of appetite. Their study could be very important in animal production as they are a

Ghrelin-mediated appetite regulation in the central nervous system

Capromorelin: a ghrelin receptor agonist and novel therapy for stimulation of appetite in dogs

The data available on the safety and effectiveness of capromorelin is reviewed, along with a discussion of the potential clinical applications for ghrelin receptor agonists in both human and veterinary medicine.

Effects of second generation antipsychotics on leptin and ghrelin

...

References

SHOWING 1-10 OF 175 REFERENCES

Ghrelin levels are not regulated by recombinant leptin administration and/or three days of fasting in healthy subjects.

Cross-sectional and interventional studies do not support a role for regulation of circulating ghrelin by leptin levels independently of changes in adiposity and suggest that the leptin and Ghrelin systems for energy homeostasis function independently of each other in healthy humans.

Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, and resistin.

This review summarizes recent knowledge on leptin and its receptor and on ghrelin, adiponectin, and resistin and emphasizes their roles in pathobiochemistry and clinical chemistry.

Leptin signaling in the hypothalamus: emphasis on energy homeostasis and leptin resistance

  • A. Sahu
  • Biology
    Frontiers in Neuroendocrinology
  • 2003

Ghrelin induces adiposity in rodents

It is proposed that ghrelin, in addition to its role in regulating GH secretion, signals the hypothalamus when an increase in metabolic efficiency is necessary, suggesting an involvement in regulation of energy balance.

Plasma ghrelin concentrations in elderly subjects: comparison with anorexic and obese patients.

Evidence of an age-related decline of plasma ghrelin concentrations is provided, which might explain, at least partially, the somatotroph dysregulation and the anorexia of the elderly subject.

Role of adipose tissue in body-weight regulation: mechanisms regulating leptin production and energy balance

  • P. Havel
  • Biology, Medicine
    Proceedings of the Nutrition Society
  • 2000
Adipose tissue performs complex metabolic and endocrine functions. Among the endocrine products produced by adipose tissue are tumour necrosis factor α, interleukin 6, acylation-stimulating protein

Leptin, gut, and food intake.

Neuroendocrine and metabolic effects of acute ghrelin administration in human obesity.

Obesity shows remarkable reduction of the somatotroph responsiveness to ghrelin, suggesting that gh Relin hyposecretion unlikely explains the impairment of somatOTroph function in obesity.

A role for ghrelin in the central regulation of feeding

It is shown that ghrelin is involved in the hypothalamic regulation of energy homeostasis and probably has a function in growth regulation by stimulating feeding and release of growth hormone.

Antagonism of ghrelin receptor reduces food intake and body weight gain in mice

Gastric peptide ghrelin and GHS-R may be promising therapeutic targets not only for anorexia-cachexia but also for obesity and type 2 diabetes, which are becoming increasingly prevalent worldwide.
...