The role of leptin and ghrelin in the regulation of food intake and body weight in humans: a review

@article{Klok2007TheRO,
  title={The role of leptin and ghrelin in the regulation of food intake and body weight in humans: a review},
  author={M. D. Klok and S. Jakobsd{\'o}ttir and M. Drent},
  journal={Obesity Reviews},
  year={2007},
  volume={8}
}
Leptin and ghrelin are two hormones that have been recognized to have a major influence on energy balance. Leptin is a mediator of long‐term regulation of energy balance, suppressing food intake and thereby inducing weight loss. Ghrelin on the other hand is a fast‐acting hormone, seemingly playing a role in meal initiation. As a growing number of people suffer from obesity, understanding the mechanisms by which various hormones and neurotransmitters have influence on energy balance has been a… Expand
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References

SHOWING 1-10 OF 179 REFERENCES
Ghrelin levels are not regulated by recombinant leptin administration and/or three days of fasting in healthy subjects.
Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, and resistin.
Leptin signaling in the hypothalamus: emphasis on energy homeostasis and leptin resistance
  • A. Sahu
  • Biology, Medicine
  • Frontiers in Neuroendocrinology
  • 2003
Plasma ghrelin concentrations in elderly subjects: comparison with anorexic and obese patients.
Leptin, gut, and food intake.
Ghrelin induces adiposity in rodents
Role of adipose tissue in body-weight regulation: mechanisms regulating leptin production and energy balance
  • P. Havel
  • Biology, Medicine
  • Proceedings of the Nutrition Society
  • 2000
Neuroendocrine and metabolic effects of acute ghrelin administration in human obesity.
Antagonism of ghrelin receptor reduces food intake and body weight gain in mice
A role for ghrelin in the central regulation of feeding
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