The role of length of nerve exposed to local anesthetics in impulse blocking action.

@article{Raymond1989TheRO,
  title={The role of length of nerve exposed to local anesthetics in impulse blocking action.},
  author={Stephen A. Raymond and Scott C Steffensen and Laverne D Gugino and Gary R. Strichartz},
  journal={Anesthesia and analgesia},
  year={1989},
  volume={68 5},
  pages={563-70}
}
The quantitative relation between the concentration of local anesthetic (LA), the length of nerve exposed, and severity of conduction blockade was studied with use of a chamber where exposure length was varied as the concentration of lidocaine was held constant. Recordings of the compound action potential and of single axons established that small variations in the length of nerve exposed to LA strongly modulate conduction block even at exposure lengths in excess of 2 cm. Therefore, exposure… CONTINUE READING