The role of large-conductance Calcium-activated K+ (BK) channels in shaping bursting oscillations of a somatotroph cell model

@inproceedings{Nowacki2018TheRO,
  title={The role of large-conductance Calcium-activated K+ (BK) channels in shaping bursting oscillations of a somatotroph cell model},
  author={Jakub Nowacki and Siti Mazlan and Hinke M. Osinga and Krasimira Tsaneva-Atanasova},
  year={2018}
}
We study a recently proposed somatotroph model that exhibit s plateau bursting, a form of electrical activity that is typical for this cell type. We focus on the influence of the large conductance (BK-type) Ca-activatedK+ current on the oscillations and duration of the active phase. The model involves two different time scales, but a standard bifurcation analysis of the fast-time limit does not completely explain the b ehavior of the model,which is subtly different from classical models for… CONTINUE READING
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