The role of kinin B1 receptor and the effect of angiotensin I-converting enzyme inhibition on acute gout attacks in rodents.

@article{Silva2016TheRO,
  title={The role of kinin B1 receptor and the effect of angiotensin I-converting enzyme inhibition on acute gout attacks in rodents.},
  author={Cassia R Silva and Sara Marchesan Oliveira and Carin Gorete Hendges Hoffmeister and Vin{\'i}cius Rafael Funck and Gustavo Guerra and Gabriela Trevisan and Raquel Tonello and Mateus Fortes Rossato and Jo{\~a}o Bosco Pesquero and Michael Bader and Mauro Schneider Oliveira and Jason J McDougall and Juliano C{\'e}sar Rego Ferreira},
  journal={Annals of the rheumatic diseases},
  year={2016},
  volume={75 1},
  pages={
          260-8
        }
}
OBJECTIVE Verify the role of the kinin B1 receptors (B1R) and the effect of ACE inhibitors (ACEi) on acute gout induced by monosodium urate (MSU) crystals in rodents. METHODS Painful (overt pain and allodynia) and inflammatory parameters (joint oedema, leukocyte trafficking, interleukin-1β levels) of acute gout attacks were assessed several hours after an intra-articular injection of MSU (1.25 or 0.5 mg/articulation) into the ankle of rats or mice, respectively. The role of B1R was… CONTINUE READING
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