The role of keratins in the digestive system: lessons from transgenic mouse models

@article{Yi2018TheRO,
  title={The role of keratins in the digestive system: lessons from transgenic mouse models},
  author={Hayan Yi and Han-Na Yoon and Sujin Kim and Nam-On Ku},
  journal={Histochemistry and Cell Biology},
  year={2018},
  pages={1-9}
}
Keratins are the largest subfamily of intermediate filament proteins. They are either type I acidic or type II basic keratins. Keratins form obligate heteropolymer in epithelial cells and their expression patterns are tissue-specific. Studies have shown that keratin mutations are the cause of many diseases in humans or predispose humans to acquiring them. Using mouse models to study keratin-associated human diseases is critical, because they allow researchers to get a better understanding of… CONTINUE READING

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