The role of kallikrein-related peptidases in prostate cancer: potential involvement in an epithelial to mesenchymal transition.

@article{Whitbread2006TheRO,
  title={The role of kallikrein-related peptidases in prostate cancer: potential involvement in an epithelial to mesenchymal transition.},
  author={Astrid K. Whitbread and Tara L Veveris-Lowe and Mitchell G. Lawrence and David Lawrence Nicol and Judith Ann Clements},
  journal={Biological chemistry},
  year={2006},
  volume={387 6},
  pages={
          707-14
        }
}
Several members of the kallikrein-related peptidase family of serine proteases have proteolytic activities that may affect cancer progression; however, the in vivo significance of these activities remains uncertain. We have demonstrated that expression of PSA or KLK4, but not KLK2, in PC-3 prostate cancer cells changed the cellular morphology from epithelial to spindle-shaped, markedly reduced E-cadherin expression, increased vimentin expression and increased cellular migration. These changes… CONTINUE READING
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