• Medicine
  • Published in Surgery 1982

The role of ischemia in acute pancreatitis: studies with an isolated perfused canine pancreas.

@article{Broe1982TheRO,
  title={The role of ischemia in acute pancreatitis: studies with an isolated perfused canine pancreas.},
  author={Patrick J. Broe and George D. Zuidema and John L. Cameron},
  journal={Surgery},
  year={1982},
  volume={91 4},
  pages={
          377-82
        }
}
Recent clinical studies have suggested that ischemia may be an important factor in the pathogenesis of acute pancreatitis. The effects of ischemia on the pancreas were investigated utilizing the isolated perfused canine pancreas. Six control glands were perfused with autologous blood with an arterial Po2 ranging from 250 to 350 mm Hg. During the 4-hour perfusion period, gross appearance remained normal, weight gain was minimal (7 gm), and mean amylase levels (853 Caraway units [CU]/dl) remained… CONTINUE READING

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