The role of iron in oxygen-mediated toxicities.

  title={The role of iron in oxygen-mediated toxicities.},
  author={Timothy P. Ryan and Steven D. Aust},
  journal={Critical reviews in toxicology},
  volume={22 2},
The transition metal iron is capable of catalyzing redox reactions between biomolecules and oxygen that would not occur if catalytically active iron were not present. Although these biological oxidations (which are known collectively as "oxidative stress") have been implicated in numerous toxicities, the exact role of the iron catalyst remains to be elucidated. This review focuses on our current understanding of the role of iron in oxidative stress, discussing biologically relevant sources… CONTINUE READING