Corpus ID: 26607427

The role of iron in nonspecific resistance to infection induced by endotoxin.

@article{Elin1974TheRO,
  title={The role of iron in nonspecific resistance to infection induced by endotoxin.},
  author={Ronald J. Elin and S. M. Wolff},
  journal={Journal of immunology},
  year={1974},
  volume={112 2},
  pages={
          737-45
        }
}
Studies using an experimental model of the mouse and Candida albicans as the challenge organism attempted to define better the mechanism of nonspecific resistance to infection induced by bacterial endotoxins. In vitro studies showed a positive correlation between the growth of C. albicans in serum from mice obtained at daily intervals for 10 days after endotoxin or saline injection and the percentage iron saturation of the serum. In vivo studies in which one of four different concentrations of… Expand
Effects of endotoxin (lipopolysaccharides) on experimental aspergillosis in leukemic mice
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Results indicate that P. aeruginosa endotoxin has a deterring effect on systemic Aspergillus infection in leukemic mice. Expand
Nonspecific resistance to infection induced in mice by a water-soluble adjuvant derived from Mycobacterium smegmatis.
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Neo-WSA is capable of inducing nonspecific resistance to certain experimental infections in mice and clearly separate this compound from bacterial endotoxins, which are classical inducers of nontoxic, water-soluble adjuvant-based resistance to infection. Expand
The critical role of iron in host-bacterial interactions.
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The gram-negative bacteria tested can be divided into four major classes according to their responses to modifications in iron levels in the chick embryo model and these results correlate with the nature of the infections which they typically produce in man. Expand
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Oral and parenteral iron administered as ammonium ferric citrate or iron dextran, respectively, were used in an attempt to reverse the bacteriostatic effect of endotoxin, which indicates that the large intestine is the primary ecological niche where campylobacters colonise mice. Expand
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This minireview examines the effects of these cytokines on nonspecific resistance to infection and the use of cytokines like IL-1, gamma interferon (IFN--y), and IL-2 as adjuvants for vaccines are beyond the scope of this review. Expand
Iron-controlled infection with Neisseria meningitidis in mice
  • B. Holbein
  • Medicine, Biology
  • Infection and immunity
  • 1980
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An iron-controlled infection was obtained after the intraperitoneal infection of Neisseria meningitidis strain M1011 into normal mice and a working hypothesis to explain the roles of iron in infection was developed: N. mening itidis obtains iron for growth from the transferrin pool, and iron dextran maintains transferrin iron levels during infection. Expand
Disseminated candidiasis. i. an experimental model in the guinea pig.
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This model will provide the framework for a series of future studies of the various factors important in natural host defense against infection with Candida, as well as the effects of various immunosuppressive agents, particularly corticosteroids, on the development and expression of immunity and protection against infection. Expand
Acute phase responses to experimental salmonellosis in calves and colibacillosis in chickens: serum iron and caeruloplasmin.
  • D. Piercy
  • Biology, Medicine
  • Journal of comparative pathology
  • 1979
TLDR
The demonstrated difference in duration of the response between host species may indicate that caeruloplasmin is associated with restoration of serum iron concentration at the end of the hypoferraemic response. Expand
Biology of endotoxin.
TLDR
This review focuses on the chemical composition, methods of detection, and some of the biological properties of bacterial endotoxins, with 'particular emphasis on the effects of these agents in human beings'. Expand
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