The role of iron in brain ageing and neurodegenerative disorders

@article{Ward2014TheRO,
  title={The role of iron in brain ageing and neurodegenerative disorders},
  author={R. Ward and F. Zucca and J. Duyn and R. Crichton and L. Zecca},
  journal={The Lancet Neurology},
  year={2014},
  volume={13},
  pages={1045-1060}
}
SUMMARY In the CNS, iron in several proteins is involved in many important processes such as oxygen transportation, oxidative phosphorylation, myelin production, and the synthesis and metabolism of neurotransmitters. Abnormal iron homoeostasis can induce cellular damage through hydroxyl radical production, which can cause the oxidation and modification of lipids, proteins, carbohydrates, and DNA. During ageing, different iron complexes accumulate in brain regions associated with motor and… Expand
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