The role of iron in T cell development and autoimmunity.

  title={The role of iron in T cell development and autoimmunity.},
  author={Christopher L Bowlus},
  journal={Autoimmunity reviews},
  volume={2 2},
Iron is a vital metal for the proliferation of all cells including those of the immune system. Iron deficiency causes several defects in both the humoral and cellular arms of immunity. One of the most profound changes is a reduction in peripheral T cells and atrophy of the thymus. The presence of transferrin receptor on immature, proliferating thymocytes and the inhibition of thymocyte proliferation and differentiation by anti-transferrin receptor antibody highlight the importance of iron to T… CONTINUE READING


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