The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during aging.

@article{Zecca2004TheRO,
  title={The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during aging.},
  author={L. Zecca and A. Stroppolo and A. Gatti and D. Tampellini and M. Toscani and M. Gallorini and G. Giaveri and P. Arosio and P. Santambrogio and R. Fariello and E. Karatekin and M. Kleinman and N. Turro and O. Hornykiewicz and F. Zucca},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 26},
  pages={
          9843-8
        }
}
  • L. Zecca, A. Stroppolo, +12 authors F. Zucca
  • Published 2004
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
In this study, a comparative analysis of metal-related neuronal vulnerability was performed in two brainstem nuclei, the locus coeruleus (LC) and substantia nigra (SN), known targets of the etiological noxae in Parkinson's disease and related disorders. LC and SN pars compacta neurons both degenerate in Parkinson's disease and other Parkinsonisms; however, LC neurons are comparatively less affected and with a variable degree of involvement. In this study, iron, copper, and their major molecular… Expand
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