The role of invariant natural killer T cells in microbial immunity.

  title={The role of invariant natural killer T cells in microbial immunity.},
  author={Yuki Kinjo and Naoki Kitano and Mitchell Kronenberg},
  journal={Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy},
  volume={19 4},
Invariant natural killer T cells (iNKT cells) are unique lymphocytes with characteristic features, such as expression of an invariant T-cell antigen receptor (TCR) α-chain, recognition of glycolipid antigens presented by CD1d molecules, and ability to rapidly produce large amounts of cytokines, including interferon-γ (IFN-γ) and interleukin 4 (IL-4) upon TCR stimulation. Many studies have demonstrated that iNKT cells participate in immune response against diverse microbes, including bacteria… CONTINUE READING


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