The role of interstitial macrophages in nephropathy of type 2 diabetic db/db mice.

  title={The role of interstitial macrophages in nephropathy of type 2 diabetic db/db mice.},
  author={Volha Ninichuk and Alexander Georg Khandoga and Stephan Segerer and Pius Loetscher and Achim Schlapbach and Laszlo Revesz and Roland Feifel and Andrej Khandoga and Fritz Krombach and Peter Jon Nelson and Detlef Schloendorff and H -J Anders},
  journal={The American journal of pathology},
  volume={170 4},
Diabetic nephropathy is associated with interstitial macrophage infiltrates, but their contribution to disease progression is unclear. We addressed this question by blockade of chemokine receptor (CCR)1 because CCR1 mediates the macrophage recruitment to the renal interstitium. In fact, when CCR1 was blocked with BL5923, a novel orally available CCR1 antagonist, the interstitial recruitment of ex vivo labeled macrophages was markedly decreased in uninephrectomized male db/db mice with advanced… CONTINUE READING
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