The role of interstitial macrophages in nephropathy of type 2 diabetic db/db mice.

@article{Ninichuk2007TheRO,
  title={The role of interstitial macrophages in nephropathy of type 2 diabetic db/db mice.},
  author={Volha Ninichuk and Alexander Georg Khandoga and Stephan Segerer and Pius Loetscher and Achim Schlapbach and Laszlo Revesz and Roland Feifel and Andrej Khandoga and Fritz Krombach and Peter Jon Nelson and Detlef Schloendorff and H -J Anders},
  journal={The American journal of pathology},
  year={2007},
  volume={170 4},
  pages={
          1267-76
        }
}
Diabetic nephropathy is associated with interstitial macrophage infiltrates, but their contribution to disease progression is unclear. We addressed this question by blockade of chemokine receptor (CCR)1 because CCR1 mediates the macrophage recruitment to the renal interstitium. In fact, when CCR1 was blocked with BL5923, a novel orally available CCR1 antagonist, the interstitial recruitment of ex vivo labeled macrophages was markedly decreased in uninephrectomized male db/db mice with advanced… CONTINUE READING
Highly Cited
This paper has 67 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 42 extracted citations

Revealing the underlying mechanism of diabetic nephropathy viewed by microarray analysis.

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association • 2015

67 Citations

0510'10'13'16'19
Citations per Year
Semantic Scholar estimates that this publication has 67 citations based on the available data.

See our FAQ for additional information.