The role of intermediary carbohydrate metabolism in regulating organic iodinations in the thyroid gland.

@article{Schussler1961TheRO,
  title={The role of intermediary carbohydrate metabolism in regulating organic iodinations in the thyroid gland.},
  author={George C Schussler and Sidney H Ingbar},
  journal={The Journal of clinical investigation},
  year={1961},
  volume={40},
  pages={1394-412}
}
As pointed out in recent reviews (1, 2), the synthesis of hormonally active materials by the thyroid gland proceeds via a sequence of seemingly discrete reactions. These may be categorized as follows: concentration of inorganic iodide from the extracellular fluid, oxidation and organic binding of iodine to yield iodotyrosines, and coupling of iodotyrosines to form the hormonally active iodothyronines. The latter two groups of reactions occur within the matrix of the thyroglobulin molecule, a… CONTINUE READING