The role of interleukin-6 in stress-induced hyperthermia and emotional behaviour in mice.

@article{Butterweck2003TheRO,
  title={The role of interleukin-6 in stress-induced hyperthermia and emotional behaviour in mice.},
  author={Veronika Butterweck and Simone Prinz and Markus Schwaninger},
  journal={Behavioural brain research},
  year={2003},
  volume={144 1-2},
  pages={49-56}
}
Psychological stress influences behaviour as well as autonomic functions such as body temperature. The mechanism that induces hyperthermia during stress is unknown. A recent hypothesis suggests that interleukin-6 (IL-6), an endogenous pyrogen, elevates body temperature during stress. To investigate the role of IL-6 during stress, we measured mRNA levels of IL-6 by quantitative PCR in various tissues 60 min after exposure of mice to open field stress. IL-6 mRNA was elevated in the hypothalamus… CONTINUE READING