The role of interleukin-6 in mucosal IgA antibody responses in vivo.

@article{Ramsay1994TheRO,
  title={The role of interleukin-6 in mucosal IgA antibody responses in vivo.},
  author={Alistair J Ramsay and Alan J. Husband and Ian A. Ramshaw and Shisan J. Bao and Klaus Ingo Matthaei and Gabriele J Koehler and Manfred Kopf},
  journal={Science},
  year={1994},
  volume={264 5158},
  pages={561-3}
}
In mice with targeted disruption of the gene that encodes interleukin-6 (IL-6), greatly reduced numbers of immunoglobulin A (IgA)-producing cells were observed at mucosae and grossly deficient local antibody responses were recorded after mucosal challenge with either ovalbumin or vaccinia virus. The IgA response in the lungs was completely restored after intranasal infection with recombinant vaccinia viruses engineered to express IL-6. These findings demonstrate a critical role for IL-6 in vivo… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 98 extracted citations

Similar Papers

Loading similar papers…