The role of interleukin-4 in IgE and IgG subclass formation

  title={The role of interleukin-4 in IgE and IgG subclass formation},
  author={Hans L. Spiegelberg},
  journal={Springer Seminars in Immunopathology},
Over the last 5 years, three major new findings were made regarding the mechanism of regulation of IgE and IgG subclass antibody formation. First, it was shown that IL-4 induces B cells to secrete IgE, murine IgG1 and human IgG4 and that IFN-γ and IL-2 inhibit this effect. Second, it was found that cloned murine T helper cells can be divided into two types: Th1, secreting IL-2 and IFN-γ; and Th2, secreting IL-4 and IL-5. Third, murine mast cells, like Th2, secrete IL-4 and IL-5 but not IL-2 and… CONTINUE READING