The role of interleukin-1 in the pathogenesis of rheumatoid arthritis.

@article{Kay2004TheRO,
  title={The role of interleukin-1 in the pathogenesis of rheumatoid arthritis.},
  author={J Kay and L Calabrese},
  journal={Rheumatology},
  year={2004},
  volume={43 Suppl 3},
  pages={iii2-iii9}
}
  • J Kay, L Calabrese
  • Published 2004 in Rheumatology
A significant body of experimental evidence has implicated the proinflammatory cytokine IL-1 in the pathogenesis of RA. For example, IL-1beta overexpression in rabbit knee joints causes arthritis with clinical and histological features characteristic of RA, whereas IL-1 deficiency is associated with reduced joint damage. In experimental models, IL-1 blockers, including IL-1 receptor antagonist (IL-1Ra), significantly reduce clinical and histological disease parameters. In RA patients, plasma… CONTINUE READING