The role of interleukin 1 in growth and metastasis of human cancer xenografts.

  title={The role of interleukin 1 in growth and metastasis of human cancer xenografts.},
  author={Dina M. Elaraj and David M. Weinreich and Sheelu Varghese and Markus Puhlmann and Stephen M. Hewitt and Nancy M. Carroll and Elizabeth D. Feldman and Ewa M. Turner and H. Richard Alexander},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={12 4},
BACKGROUND Interleukin 1 (IL-1) is a pluripotent cytokine that promotes angiogenesis, tumor growth, and metastasis in experimental models; its presence in some human cancers is associated with aggressive tumor biology. The purpose of these studies was to characterize the role of IL-1 in human cancers and determine if inhibition of IL-1 via its receptor antagonist, IL-1Ra, alters tumor growth and metastatic potential. METHODS IL-1 mRNA or protein levels were determined in clinical tumor… CONTINUE READING
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Altered expression of several genes in highly metastatic subpopulations of a human pulmonary adenocarcinoma cell line

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  • EurJCancer
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