The role of interferons in early pregnancy

@article{Micallef2014TheRO,
  title={The role of interferons in early pregnancy},
  author={Annalise Micallef and Nicole Grech and Francesca Farrugia and Pierre Schembri-Wismayer and Jean Calleja-Agius},
  journal={Gynecological Endocrinology},
  year={2014},
  volume={30},
  pages={1 - 6}
}
Abstract The interferons (IFNs) form part of the large family of glycoproteins known as cytokines. They are secreted by host cells as a line of defence against pathogens and certain tumours. IFNs affect cell proliferation and differentiation and also play a very important role in the functioning of the immune system. Miscarriage in both humans has been associated with higher levels of IFN, particularly IFN-γ. However, this cytokine is evidently vital in successful murine pregnancies since it is… 

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References

SHOWING 1-10 OF 98 REFERENCES

Interferon Gamma in Successful Pregnancies1

The dynamic roles of IFNG in successful pregnancy is described and data onIFNG in gestational pathologies is summarized.

Interferon-tau, a Type 1 interferon involved in maternal recognition of pregnancy.

  • R. Roberts
  • Biology
    Cytokine & growth factor reviews
  • 2007

Biologic effects of interferons.

  • I. Gresser
  • Biology, Medicine
    The Journal of investigative dermatology
  • 1990
It is believed that IFN is an integral part of a cytokine network and that they and other cytokines may be produced constitutively at low levels and these substances exert multiple effects on virtually all cells.

Interferons and viral infections

The effectiveness of theinterferon system in counteracting viral infections is reflected by the multitude of inhibitors of interferon induction or interferons action that are encoded by many viruses, preventing their eradication and resulting in the continued coexistence of viruses and vertebrates.

Immunopathology of Early Pregnancy

There is still room for discussing, and re-envisaging, with the use of murine models and data in humans, the concept and mechanisms of "rejection" of the foetal allograft, but the question of the tolerance of the conceptus has evolved.

NK cells and human pregnancy--an inflammatory view.

Regulatory Roles of IFN‐Gamma in Human Endometrium a

  • S. Tabibzadeh
  • Biology, Medicine
    Annals of the New York Academy of Sciences
  • 1994
This cytokine may be the prototype of a group of paracrine factors that induce a polarized microenvironment in human endometrium and emerging evidence suggests that the development of this microenvironment is mediated by T cells activated within lymphoid aggregation with consequent secretion of IFN-gamma.

A review of immune cells and molecules in women with recurrent miscarriage.

Although much of the evidence is contradictory, these studies do suggest differences in the expression of some immune cells and molecules in women with RM, and the importance of compartment, timing and the timing of the sampling is emphasized.

Expression of cytokines in placentas of mice undergoing immunologically mediated spontaneous fetal resorptions.

Since these cytokines are abortifacients in vivo and have detrimental effects on the placenta, and hence on fetal development and survival, the demonstration of enhanced expression of these deleterious cytokines may give insight into the mechanisms involved in immunologically mediated spontaneous abortions.

The molecular cell biology of interferon-gamma and its receptor.

This review focuses on the new developments in the areas of IFN gamma biochemistry and biology and pays particular attention to the IFN Gamma receptor and three aspects of IFn gamma biology that are of special interest to immunologists: host defense, inflammation, and autoimmunity.
...