The role of interferon regulatory factor-1 in cytokine-induced mRNA expression and cell death in murine pancreatic beta-cells.

@article{Pavlovic1999TheRO,
  title={The role of interferon regulatory factor-1 in cytokine-induced mRNA expression and cell death in murine pancreatic beta-cells.},
  author={Dejan Pavlovic and M C Chen and Conny A. Gysemans and Chantal Mathieu and Decio L. Eizirik},
  journal={European cytokine network},
  year={1999},
  volume={10 3},
  pages={403-12}
}
Combinations of cytokines, including interleukin-1beta (IL-1beta) and interferon-gamma (IFN-gamma), induce nitric oxide (NO) production and cell death in pancreatic islet cells. We have previously shown that these events are preceded by increased expression of the transcription factor interferon regulatory factor-1 (IRF-1). We utilized an IRF-1 knockout mouse (IRF-1-/-) to investigate the role of IRF-1 in cytokine-induced islet- and beta-cell gene expression and cell death. For this purpose… CONTINUE READING

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