The role of interferon in influenza virus tissue tropism.

  title={The role of interferon in influenza virus tissue tropism.},
  author={Adolfo Garc{\'i}a-Sastre and Russell K. Durbin and Hongyong Zheng and P. Palese and Rachel Gertner and David E. Levy and Joan E Durbin},
  journal={Journal of virology},
  volume={72 11},
We have studied the pathogenesis of influenza virus infection in mice that are unable to respond to type I or II interferons due to a targeted disruption of the STAT1 gene. STAT1-/- animals are 100-fold more sensitive to lethal infection with influenza A/WSN/33 virus than are their wild-type (WT) counterparts. Virus replicated only in the lungs of WT animals following intranasal (i.n.) virus inoculation, while STAT1-/- mice developed a fulminant systemic influenza virus infection following… CONTINUE READING