The role of interferon alpha in initiation of type I diabetes in the NOD mouse.

@article{Li2011TheRO,
  title={The role of interferon alpha in initiation of type I diabetes in the NOD mouse.},
  author={Qing Li and Hugh O Mcdevitt},
  journal={Clinical immunology},
  year={2011},
  volume={140 1},
  pages={3-7}
}
Type 1 diabetes (T1D) is an autoimmune disease in both humans and the nonobese diabetic (NOD) mouse, in which the insulin-producing-cells of the pancreatic islets are destroyed by a beta islet cell-specific T cell immune response. We recently reported that interferon (IFN)-α is an early trigger of the T1D process in NOD mice. Here, we show that extensive blockade of IFN-α action by a monoclonal antibody specific to IFN-α receptor 1 results in nearly complete prevention of T1D in NOD mice… CONTINUE READING