The role of insulin receptors and IGF-I receptors in cancer and other diseases.

@article{Frasca2008TheRO,
  title={The role of insulin receptors and IGF-I receptors in cancer and other diseases.},
  author={F. Gaudiello S. Frasca and G Pandini and Laura Sciacca and Vincenzo Pezzino and Sebastiano Squatrito and Antonio Belfiore and Riccardo Vigneri},
  journal={Archives of physiology and biochemistry},
  year={2008},
  volume={114 1},
  pages={23-37}
}
There is evidence, both in vitro and in vivo, that receptor tyrosine kinases play a key role in the formation and progression of human cancer. In particular, the insulin-like growth factor receptor (IGF-IR), a tyrosine kinase receptor for IGF-I and IGF-II, has been well documented in cell culture, animal studies, and humans to play a role in malignant transformation, progression, protection from apoptosis, and metastasis. In addition, the hormone insulin (which is very closely related to the… CONTINUE READING
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