The role of insulin in human brain glucose metabolism: an 18fluoro-deoxyglucose positron emission tomography study.

@article{Bingham2002TheRO,
  title={The role of insulin in human brain glucose metabolism: an 18fluoro-deoxyglucose positron emission tomography study.},
  author={Emma M Bingham and D. Hopkins and Diarmuid Smith and Andrew Pernet and William A. Hallett and Laurence J. Reed and Paul K. Marsden and Stephanie A. Amiel},
  journal={Diabetes},
  year={2002},
  volume={51 12},
  pages={3384-90}
}
The effect of basal insulin on global and regional brain glucose uptake and metabolism in humans was studied using 18-fluorodeoxyglucose and positron emission tomography (FDG-PET). Eight healthy male volunteers aged 49.3 +/- 5.1 years were studied twice in random order. On each occasion, they received an infusion of 0.1 mg. kg(-1). min(-1) somatostatin to suppress endogenous insulin production. In one study 0.3 mU. kg(-1). min(-1) insulin was infused to replace basal circulating insulin levels… CONTINUE READING
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