The role of insulin in fetal growth.

  title={The role of insulin in fetal growth.},
  author={Abigail L Fowden},
  journal={Early human development},
  volume={29 1-3},
Disturbances in fetal insulin secretion are associated with abnormalities in fetal growth in a variety of species: excessive insulin secretion can lead to fetal macrosomia while fetal hypoinsulinaemia invariably causes fetal growth retardation. Fetal insulin deficiency caused by pancreatectomy (PX) of the sheep fetus leads to reduced body weight, crown-rump length and limb lengths at delivery near term. The growth rate in utero fell by 40-50% after PX and could be restored to normal values by… CONTINUE READING


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