The role of insulin dependent NO synthesis in the impaired production of maspin in human breast cancer

@article{Girish2006TheRO,
  title={The role of insulin dependent NO synthesis in the impaired production of maspin in human breast cancer},
  author={Gannareddy V. Girish and Gorachand Bhattacharya and Asru Kumar Sinha},
  journal={Journal of Cancer Research and Clinical Oncology},
  year={2006},
  volume={132},
  pages={389-398}
}
Purpose: The synthesis of maspin, a protein with various anti-breast cancer properties has been reported to be produced in normal breast tissue but not in breast cancer cells. We investigated the role of insulin receptors and their upregulation by prostaglandin E1 in vitro for the stimulation of NO synthesis by the hormone, and its consequence on maspin production in normal neutrophils and malignant cells in breast cancer. Methods: Maspin and NO were determined by ELISA and methemoglobin method… CONTINUE READING
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