The role of insulin/IGF-1 signaling in the longevity of model invertebrates, C. elegans and D. melanogaster

@inproceedings{Altintas2016TheRO,
  title={The role of insulin/IGF-1 signaling in the longevity of model
invertebrates, C. elegans and D.
melanogaster},
  author={Ozlem Altintas and Sangsoon Park and Seung-Jae V Lee},
  booktitle={BMB reports},
  year={2016}
}
Insulin/insulin-like growth factor (IGF)-1 signaling (IIS) pathway regulates aging in many organisms, ranging from simple invertebrates to mammals, including humans. Many seminal discoveries regarding the roles of IIS in aging and longevity have been made by using the roundworm Caenorhabditis elegans and the fruit fly Drosophila melanogaster. In this review, we describe the mechanisms by which various IIS components regulate aging in C. elegans and D. melanogaster. We also cover systemic and… CONTINUE READING