The role of innate immune responses in autoimmune disease development.

@article{Waldner2009TheRO,
  title={The role of innate immune responses in autoimmune disease development.},
  author={Hanspeter Waldner},
  journal={Autoimmunity reviews},
  year={2009},
  volume={8 5},
  pages={400-4}
}
Autoimmune diseases are systemic or organ-specific disorders that are the result of an attack of the immune system against the body's own tissue. Development of autoimmune disease is generally avoided by distinct mechanisms that silence adaptive self-reactive T or B cells. The innate immune system is critically involved in the defense against pathogens and the induction of primary adaptive immune responses. Toll-like receptors (TLRs) are key receptors that activate the innate immunity in… CONTINUE READING

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