The role of inhibitory heterotrimeric G proteins in the control of in vivo heart rate dynamics.

@article{Zuberi2008TheRO,
  title={The role of inhibitory heterotrimeric G proteins in the control of in vivo heart rate dynamics.},
  author={Zia Zuberi and Lutz Birnbaumer and Andrew Tinker},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2008},
  volume={295 6},
  pages={
          R1822-30
        }
}
Multiple isoforms of inhibitory Galpha-subunits (Galphai1,2,3, as well as Galphao) are present within the heart, and their role in modulating pacemaker function remains unresolved. Do inhibitory Galpha-subunits selectively modulate parasympathetic heart rate responses? Published findings using a variety of experimental approaches have implicated roles for Galphai2, Galphai3, and Galphao in parasympathetic signal transduction. We have compared in vivo different groups of mice with global genetic… CONTINUE READING
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